Intracellular lithium
نویسندگان
چکیده
منابع مشابه
Accumulation and intracellular compartmentation of lithium ions in Saccharomyces cerevisiae.
Accumulation of Li+ in Saccharomyces cerevisiae X2180-1B occurred via an apparent stoichiometric relationship of 1:1 (K+/Li+) when S. cerevisiae was incubated in the presence of 5 and 10 mM LiCl for 3 h. Other cellular cations (Mg2+, Ca2+ and Na+) did not vary on Li+ accumulation, although lithium chemistry dictates a degree of similarity to Group I and II metal cations. Compartmentation of Li+...
متن کاملchronic lithium treatment increased intracellular s100ß levels in rat primary neuronal culture.
s100ß a neurotrophic factor mainly released by astrocytes, has been implicated in the pathogenesis of bipolar disorder. thus, lithium may exert its neuroprotective effects to some extent through s100ß. furthermore, the possible effects of lithium on astrocytes as well as on interactions between neurons and astrocytes as a part of its mechanisms of actions are unknown. this study was undertaken...
متن کاملLithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland.
The effects of lithium and cholinergic stimulation on inositol phospholipid metabolism have been assessed using rat parotid gland slices and isolated acinar cells labelled with 32Pi. Cholinergic stimulation using carbachol caused substantial breakdown of phosphatidylinositol 4,5-bisphosphate (PtdInsP2) and enhanced labelling of phosphatidate (PA) and phosphatidylinositol (PtdIns). Lithium alone...
متن کاملIntracellular lithium and cyclic AMP levels are mutually regulated in neuronal cells.
In this work, we studied the effect of intracellular 3',5'-cyclic adenosine monophosphate (cAMP) on Li+ transport in SH-SY5Y cells. The cells were stimulated with forskolin, an adenylate cyclase activator, or with the cAMP analogue, dibutyryl-cAMP. It was observed that under forskolin stimulation both the Li+ influx rate constant and the Li+ accumulation in these cells were increased. Dibutyryl...
متن کاملEffect of lithium on the intracellular potassium concentration in sheep heart Purkinje fibres.
Simultaneous measurements were made of the intracellular activities of potassium and lithium in sheep heart Purkinje fibres using ion-sensitive microelectrodes. On exposure of the fibres to lithium, the intracellular activity of lithium rose, with an equivalent decrease in the level of intracellular potassium.
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 1977
ISSN: 0028-3908
DOI: 10.1016/0028-3908(77)90012-0